herbs for autoimmune disease
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Autoimmune diseases such as rheumatoid arthritis (RA), ankylosing spondylitis, and systemic lupus erythematosus (SLE), involve destruction of healthy cells by the body’s own defensive mechanism. If the immune system’s faux pas is not corrected, the attack can progress to the heart, lungs, and other vital organs. The mechanisms that cause the deregulation of the immune response are not entirely understood. It can be assumed that heavy metal toxicity, leaky gut syndrome, infectious bacteria and parasites, and nutritional imbalances can overburden the body’s immune system, thus deregulating immune signals and responses. Ongoing research investigates the mechanism by which these factors cause the immune system to attack the body’s own tissues. In this paper, we discuss natural therapies that can help regulate the immune system’s aggressive behavior without suppressing or altering its necessary defenses.
The immune system constantly surveys the body for foreign (“non-self”) substances, such as cancerous cells, bacteria, viruses, parasites, foreign proteins and chemical insults. During a normal immune response, leukotrienes and prostaglandins dilate blood vessels so that immune components can quickly travel to the area that needs protection. Increased blood flow causes swelling, redness, and heat. Another wave of pro-inflammatory compounds, chemotactic factors (also known as cytokines), activate the white blood cells to begin attacking damaged cells and pathogens. As pathogens are destroyed, their cell walls and internal components leak out, triggering still another phase of immune defense. B cells produce antibodies specific to the pathogen or cell under attack, and also alert macrophages that invaders are present. The oxidizing chemicals released by white blood cells to destroy pathogens can inadvertently affect normal cells. The healthy cells surrounding an inflammatory response attempt to protect themselves by secreting anti-inflammatory prostaglandins, antioxidants, anti-chemotactic chemicals, and enzymes. All of these chemicals counter the destructive substances released by white blood cells, protecting against ‘collateral damage’ to healthy tissue. When the body is functioning normally, pro-inflammatory cytokines are soon suppressed by the anti-inflammatory cytokines secreted by neighboring cells. The inflammatory response subsides; suppressor T cells stop the production of antibodies, blood vessels return to their normal size, and the repair process begins to mend damaged tissue.
In autoimmune diseases, the immune response continues unabated even if there is no foreign invader to attack. The exact sequence of events that lead the immune system to turn against the body, has yet to be determined. However, Nuclear factor kappa beta (NFkB) regulators, pro-inflammatory prostaglandins, auto-antibodies, and defective suppressor T cells have been identified as suspects in deregulating the immune response.
High levels of inflammatory agents spur the immune system into constant activity. Initially, the immune system raises its defenses against foreign substances only. With prolonged inflammatory stress however, the immune system will turn against its host and attack the body’s own tissues, thus establishing a classical autoimmune disease. Herbs that reduce inflammation may help down-regulate the autoimmune response. Several herbs that have been traditionally used for this purpose also have been investigated scientifically to determine their mechanism(s) of action. These herbs include: Hops, Artemisia, Sarsaparilla, Reishi Mushroom, Ashwagandha, Nettle, Rehmannia, and Chinese Skullcap (Scute). Other important herbs that may have a role in decreasing both inflammation and the overzealous autoimmune response include Boswellia serrata, Green Tea, Ginger, Turmeric, White Willow, Stephania and Chinese Thunder God Vine.
Hops is a rambling vine and member of the Cannabinacea family, which has traditionally been used in herbal medicine as a nervine and sedative. It also is a plant of economic importance in the production of beer. Recent research into the plant shows it has excellent potential for the management of pain and inflammation associated with rheumatologic issues. In one clinical trial, Hops exhibited Cox-2 inhibition over 9 hours, equivalent to ibuprofen 400 mg but had significant Cox-1 sparing activity relative to ibuprofen. The authors of this article concluded that Hops extracts may represent a safe alternative to ibuprofen for non-prescription anti-inflammation.
Autoimmune diseases can be devastating. While some are more well known, such as lupus and rheumatoid arthritis, there are hundreds of diseases where the body’s own immune system turns on itself. Rather than protecting the body from outside threats, the immune system sees the body itself as a threat and reacts accordingly.
While there are drugs to treat autoimmune diseases, many people prefer more natural methods or to blend the two. The following are herbs that work best to support the body’s immune system while reducing its attack on the body.
Commonly used in beer, hops actually have sedative and anti-inflammatory properties. The herb has been studied and shown to be a safe alternative to ibuprofen for reducing inflammation in autoimmune flares.
Recipe: The best way to use hops is to turn them into an extract. This may be done by soaking two oz. of fresh hops in two cups of vodka for six weeks. You can also purchase hops extract. While making tea from hops is another option, it doesn’t allow for the full effect, but is a good alternative if you’re avoiding alcohol. To make tea, add one or two hops to a cup of boiling water and steep for five minutes. You can take this tea daily or two mg. of the extract.
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